SMD College, Mathura, is a co-educational NCTE-affiliated institution. SMD College follows an admission process to select deserving students for its various undergraduate and postgraduate courses. The admission phase at SMD College typically moves in line with the academic session that typically commences between July or August. Eligibility criteria vary for the chosen programme, though.

For undergraduate courses like BA, B. Sc, and BBA, the applicants must have passed Intermediate (10+2) studies. For B. Sc, science stream studies are mandatory. Postgraduate courses like M. Com and MBA typically require a corresponding bachelor's degree. The B. Ed course, for instance, has the minimum requirement of 50% marks in a Bachelor's or Master's degree, or 55% marks in B. Tech with Mathematics and Science.